â€œKB220Z Nutrigenomic Neuroadaptogenâ€ is the current research code for the nutraceutical technology called Endorphamine™ in the Brain Reward formula. However, over the years, other names and/or research codes for the same technology have been used such as SG8839, LG839, Synaptamine, Haveos, SAAVE, PCAL-I03, KB220, etc. All of these names and/or codes are for research on the patented and patent-pending foundational technology as it has evolved, been added to, and culminated in the present KB220Z technology.
Brain Reward HistoryClick Here For Abstracts
Journal of Psychoactive Drugs
Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot StudyDecember issue 2012).
Cross over tripleâ€“blindâ€“placebo controlled study
Neurotransmitter-precursor-supplement Intervention for Detoxified Heroin Addicts.Early 2012
â€œDopamine Resistanceâ€ in brain reward circuitry
â€œDopamine Resistanceâ€ in brain reward circuitry as a function of DRD2 gene receptor polymorphisms in RDS: Synaptamine complex variant (KB220) induced â€œDopamine Sensitivityâ€ and enhancement of happiness.2011
Overcoming qEEG abnormalities and reward gene deficits
Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine Dâ‚‚ agonist therapy: part 2.2010
Acute intravenous synaptamine complex variant KB220™
Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports.2010
Sustainable Weight Loss and Muscle Gain
Sustainable Weight Loss and Muscle Gain Utilizing the Rainbow Diet™: Targeting Noradrenergic and dopaminergic Mechanistic Sites, Hormonal Deficiency Repletion Therapy and Exercise: A case report.2010
Putative targeting of Dopamine
Putative targeting of Dopamine D2 receptor function in Reward Deficiency Syndrome (RDS) by Synaptamine Complex™ Variant (KB220): Clinical trial showing anti-anxiety effects.2009
Dopamine D2 Receptor Taq A1
Putative targeting of Dopamine D2 receptor function in Reward Deficiency Syndrome (RDS) by Synaptamine Complex™ Variant (KB220): Clinical trial showing anti-anxiety effects.2008
LG839: anti-obesity effects
LG839: anti-obesity effects and polymorphic gene correlates of reward deficiency syndrome.2008
Efficacy and safety of LG839
A short term pilot open label study to evaluate efficacy and safety of LG839, a customized DNA directed nutraceutical in obesity: Exploring Nutrigenomics.2007
Nutrient Induces Changes In Body
Chromium Picolinate (Crp) A putative Anti-Obesity Nutrient Induces Changes In Body Composition As Function Of The Taq1 Dopamine D2 Receptor Gene.2007
- Research Extends to 1973
This is why 100% of the weight loss products and programs fail more than 95% of the time in 2 to 5 years. With more than 6 decades of weight loss tactics, products, and programs, the overwhelming evidence indicates that conventional strategies to 'lose weight' are not working. The vast majority of these strategies have used 1 or more of the following types of failed tactics to reduce heaviness.
Deprivation: Reducing the intake or impact of calories by various mechanisms (i.e. appetite suppressants, fat blockers, starch blockers, water absorbing fiber-water-fill-you-up pre-meal bulking agents, etc.). Collectively these tactics are called 'Deprivation' because they are intended to deprive the body of caloric impact and the supposed consequential fat (weight) gain caused by those calories.
Stimulation: Stimulating fat burning or the central nervous system to burn more calories than are taken in. There are many nutraceutical products that exert this kind of action (i.e. synephrine, caffeine, cola nut, guarana, salicylic acid, DMAA, Yohimbine, etc.).
- Excessive Exercise: This is most often also used to burn more calories than are consumed.
- Elimination: Promoting aggressive urinary and/or bowel elimination by various kinds of aggressive fibers, diuretics, and laxatives, etc.
Note: Fat is 'survival energy' insurance. As such, ALL of these tactics, alone or in combination work against the body's mandated genetic survival defense system, which ultimately increases 'survival panic' and causes a defensive response to these forceful tactics by: 1. Turning down cellular energy production (for energy conservationâ€¦aka 'survival'), 2. Increasing fat storage (fat is survival insuranceâ€¦i.e. also energy conservation), and 3. Increasingcravings to increase food (energy) consumption.
Conventional dogma states that people are fat because 'they eat too much and don't exercise enough'...and we categorically accept this dogma because it seems logical. However, if this was the actual reason, then everyone who ate less and exercised more would be thinner (or lighter) than everyone who didn'tâ€¦and we know this is NOT the case. There are 3 primary causes of ill health, including obesity and other conditions.
- Poor lifestyle choices: This includes taking in not enough of the good stuff that keeps us healthy (i.e. nutritional deficiencies, etc.); and getting too much of the bad stuff that makes us unhealthy (i.e. toxic chemical & environmental pollutants, EMFs, etc.).
- (Dis)Stress: Excessive stressful burdens contribute to â€œtoo much of the badâ€ in #1 immediately above.
- Genetic predispositions: Genetic predispositions are a major contributor to Reward Deficiency Syndrome behaviors (more on this later). We can't change our genes, but we can change ('make a corrective adjustment' ala 'Optimize') our Gene Expression.
Epigenetics is the science that studies how lifestyle choices influence gene expression and overall health. â€œNutrigenomicsâ€ is the science within Epigenetics that studies how nutritional choices affect gene expression and how that influences overall health.
So, the issue is not THAT fat people eat too much and don't exercise enough; the question is 'WHY'? Obesity and overweight area 'deficient energy' and metabolic regulation crisis (not just a heaviness crisis), which requires a nutri-genetic (nutrigenomic) approach to promoting optimal brain function. What is required is correcting the gene expression and metabolic retardation that caused excessive energy conservation (from survival panic), which turned down energy production (in the muscles...aka 'muscle sluggishness' and fatigue), increased fat storage, and increased cravings (both in the brain and at the cellular level). Anything that induces survival panic, like excessive stress, nutrient deficiencies, and toxic load, ultimately cause energy conservation and fat gain. This is especially relevant in people who have genetic predispositions in the reward and survival centers of the brain that results in a much more aggressive response to such factors.
BRAIN REWARD works by replenishing the nutritional needs of the Brain Reward Cascade (BRC), relieving stress, and optimizing gene expression in the BRC; addressing all 3 factors that contribute to reduced health. Moreover, because BRAIN REWARD nutritionally relieves 'survival panic', it thereby allows the body to turn on permissible energy expenditure, regulate cravings (reduce & change), promote neuroendocrine competence, and bolster immune strength. This is what is first required for the body to let go of excess fatâ€¦ala 'survival insurance' and improve sustainable lean body composition.
Last year I had to lose about 25 pounds to fit into a dress for an upcoming wedding. I had two months to lose the weight. I took a weight loss product, went on a fasting program, and started an aggressive exercise regimen. I lost the weight and got into that dressâ€¦I looked great and enjoyed the tremendous satisfaction from my achievement! Since then, I've gained back about 5 more pounds than I lost. Can't I just go back on that program again?
Don't do it! (I guess that's not enough of an answer.) Rapid weight loss programs, especially a chain of numerous repetitions of those programs, literally wreak havoc on the body's survival security system, which disrupts energy regulation by throwing the body into a panicked state of extreme energy conservation (resulting in increased fat storage, fatigue, and excess cravings). Rapid weight loss programs may be a greater contributor to the obesity epidemic, especially for those with genetic predispositions, than that caused by poor diet alone.
This is one of the most common occurrences with weight loss programs. Recall that research indicates 100% of weight loss programs fail more than 95% of the time in 2 to 5 years. However, very often continued compliance in the early weeks of a program is poor exactly for the reasons you indicate. People see the 'scale weight' losses level off and stay at the same number for a while (the 'plateau') and then start to creep back up again, oftentimes surpassing the weight at which they started the programâ€¦even those that are engaging in vigorous exercise programs. This is called 'Yo-Yo rebound weight gain' or just a 'Yo-Yo diet'. Because of the genetic survival defense, they often gain more 'fat' weight back than was originally lost. They get so disappointed and just quit their program in defeat. There are reasons for this. However, some healthy 'weight gain' is entirely predictable.
Even when the weight loss program is healthy by any standards, there are some factors that frustrate 'weight loss' efforts (that is 'reducing heaviness') based on the bathroom scale. Fat is lighter than water, muscle, and bone; fat is the lightest of these macromolecules. Muscle cells are the primary and most abundant energy factories in the body. When the body is in a state of chronic survival distress, it goes into a state of energy conservation (see the first Question), which programs a 'down regulation' (reduction) in the muscle cells' ability to make energy; the muscle cells essentially try to go into a dormant stateâ€¦a sort of muscle cell atrophy. The body just doesn't want to make (expend) energy; it wants to conserve energy. The body also increases fat storage and food (energy) cravings. Not surprisingly, along with the increase in cravings & food consumption, fatigue can also increase, which reduces the desire to be active (more energy conservation)â€¦even creating the appearance of laziness.
When the body once again allows itself to start making energy, it 'kick starts' energy production, which initially causes an increased elimination of excess water and CO2 (carbon dioxide), the byproducts of energy production. Since water is heavier than fat (and takes up volume [size]), you see a reasonably quick reduction in heaviness (weight) and a modest reduction in size (the â€œYippeeâ€ response). But, eventually the body needs to restore a much greater ability to make more energy and starts rebuilding the nearly dormant energy factories in the muscle cells (mitochondria), which causes a mild increase in heaviness (because muscle is heavier than the fat and water that was lost). But, you generally don't see an increase in size, because muscle takes up a lot less space (volume) for the increased heaviness that results. But, most people (even professionals) don't understand this natural process, get frustrated and disappointed by the weight plateau and gains. It is common for the individual to get more aggressive with increased calorie deprivation, stimulation, and elimination tactics, and maybe increased intensity of their exercise regimen, the result of which reinstates' survival panic'â€¦and the Yo-Yo rebound weight gain process starts again and gains fat & water storage momentum.
So, since muscle is heavier than fat, "losing weight" is an inaccurate measurement of what can happen during the process of improving lean body composition. The weight scale may initially decrease (from water loss), then slightly increase (from muscle weight gain), then, decrease (when enough fat and water are lost to offset the heavier muscle weight gains). When this process has got some momentum, the weight scale gradually goes down, but size has already been decreasing, even if (muscle) weight has increased a bit. The message...STAY OFF THE SCALE!
In general, it is mostly true. But, it is flawed for a number of reasons; the first being the definition of â€œhealthy balanced diet.â€ We cannot delve into this particular aspect in any great depth here. But, suffice it to say that the questionable quality of foods in our markets is a serious concern, especially those produced by standard agribusiness factory farms and food processing technologies.
On a more relevant point, as mentioned in another answer, there are 3 main reasons people are unhealthy:
Poor lifestyle choices: This includes taking in not enough of the good stuff that keeps us healthy (i.e. nutritional deficiencies, etc.); and getting too much of the bad stuff that makes us unhealthy (i.e. toxic chemical & environmental pollutants, EMFs, etc.).
(Dis)Stress: Excessive stressful burdens contribute to â€œtoo much of the badâ€ in #1 immediately above.
Genetic predispositions: Genetic predispositions are a major contributor to Reward Deficiency Syndrome behaviors (more on this later). We can't change our genes, but we can change ('make a corrective adjustment' ala 'Optimize') our Gene Expression.
Over 30% of the US population carries a genetic predisposition that increases the susceptibility to greater consequences from stress and risk of excessive obsessive, compulsive, impulsive, and addictive behaviors. This particular genetic predisposition is the dopamine D2 receptor gene, Taq I A1 variant (called an 'allele' or polymorphism); generally it is referred to simply as the 'DRD2 A1 gene'. This is the â€œreward geneâ€ (also called â€œthe addiction geneâ€) that was discovered by Kenneth Blum, Ph.D. and Ernest Noble, Ph.D. and reported in JAMA in 1990. By the way, the rate of obesity is just over 30% of Americans (not a coincidence that it is the same as the rate of obesity). People who carry this gene have 30% to 40% less dopamine D2 receptors. This causes dopamine resistance and an increased need for a pleasure satisfying 'dopamine fix', because dopamine is your happy, feel good, anti-stress, and will-power neurotransmitter (among others). People that carry this gene routinely have â€œReward Deficiency Syndromeâ€ because it takes much more dopamine stimulating thoughts, behaviors, and substances (like sugar, drugs, food, etc.) to produce enough dopamine just to feel good (or normal).
In these cases, even eating the so-called healthy diet most often doesn't provide enough nutritional support to answer the need for more dopamine satisfaction. BRAIN REWARD is apatented KB220Z Nutraceutical Neuroadaptogen (US Patents 6,132,724, 6,955,873, and EU Patent EPO979092) and provides the only known evidence-based natural and effective dopamine agonist, supported by 27 studies (to date) that nutritionally supports optimal dopamine sensitivity and function*. BRAIN REWARD balances the neurochemistry in the brain reward cascade, culminating with dopamine*.
BRAIN REWARD contains some special forms and specific amounts of amino acids that are very important in the manufacturing of neurotransmitters in the brain reward cascade (BRC). If the supplements you are taking, or the food you are eating contain proteins or amino acids, then you will increase the possibility that these proteins or amino acids would compete for absorption and function and interfere with or prevent the absorption and/or work in opposition of each other once inside the cells. It is called 'competitive inhibition'. In effect, you could significantly diminish the benefits of either by taking them together, which would be a waste of money.
Various types of nutrients that go through the digestive process have different absorption sites and rates. Some nutrients are absorbed pretty fast and some take much longer. Moreover, digestive health and absorption rates vary between people. However, the number one reason for emergency room visits in the US is digestive problemsâ€¦it is an epidemic. So, the Molecular Self Assembly (MSA) liposome encapsulated nano technology is designed to bypass the need for digestive disintegration and dissolution of nutrient components and gain rapid access to the blood stream and targeted tissues. All of the cells in the GI tract are phospholipid loving. The liposome capsule is a phospholipid that is effortlessly absorbed with its ingredient payload. The reports from the field indicate extremely rapid biological activity.
Moreover, a study published in the Journal of Medicinal Food in 2007, reported on a comparison of identical formulations of CoQ10 & Vitamin E, one in a conventional sofgel capsule and the other a liposomal preparation (LP). The CoQ10 from the LP increased bioavailability by 5-fold over the non-LP CoQ10, and bioavailability of the LP of vitamin E was enhanced 10-fold over the standard non-LP form [Wajda R, Zirkel J, and Schaffer T. Increase of Bioavailability of Coenzyme Q10 and Vitamin E. J Med Food; 10 (4): 731â€“734 (2007)].
No! One of the roles of phenylalanine is as a building block for Dopamine. Dopamine is an anti-stress and reward neurotransmitter. This is why deficits in dopamine tend to lead to "excessive reward seeking behaviors" like for over indulging in food, alcohol, drugs, sex, gambling, etc Sufficient dopamine causes a feeling of satisfaction, contentment, and even happiness, not stimulation per se. There are over 40 years of research by world renowned neuro-psychopharmacologists, like Dr. Kenneth Blum,the father of psychiatric genetics, supporting the crucial roles of all the ingredients in BRAIN REWARD.
No relation whatsoever.
Aspartame breaks down into phenylalanine, aspartic acid, and methanol, which further breaks down into formaldehyde. Do we know the effect of adding additional phenylalanine to people already ingesting aspartame though diet drinks? Will this increase the danger of using aspartame? For those of who don't use any artificial sweeteners, how can we be assured that taking phenylalanine doesn't produce the same effects that aspartame does?
Phenylalanine is an essential amino acid. That means that if you don't put it into your mouth your body cannot make it and you will suffer the consequences of deficiencies. That also means that a different question needs to be asked. And, that is, "If taking the BRAIN REWARD can reduce excess sugar craving, am I able to reduce the amount of "artificial" sweeteners that I use?" The answer is, "probably yes!" For the most part, artificial sweeteners have been chemically altered. The amino acids in BRAIN REWARD are in their natural 'body-friendly' state, not chemically altered.